Axonopathy Research Group

2023

Sang-Heum Han;Young Hee Kim;Su-Jeong Park;Jun-Gi Cho;Yoon Kyung Shin; Young Bin Hong; Jeanho Yun; Jin-Yeong Han; Hwan Tae Park;Joo-In Park. COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20. J Neurochem. 2023 Jun;165(5):660-681. PMID: 36648143

Shin, Yoon Kyung; Jo, Young Rae; Lee, Seoung Hoon; Park, Hwan Tae; Shin, Jung Eun; Regulation of the V-ATPase subunit ATP6V0D2 and its role in demyelination after peripheral nerve injury. Biochem Biophys Res Commun. 2023 Feb 26;646:1-7. PMID: 36689911

Jo, Young Rae; Oh, Yuna; Kim, Young Hee; Shin, Yoon Kyung; Kim, Hye Ran; Go, Hana; Shin, Jaekyoon; Park, Hye Ji; Koh, Hyongjong; Kim, Jong Kuk; Shin, Jung Eun; Lee, Kyung Eun; Park, Hwan Tae; Adaptive autophagy reprogramming in Schwann cells during peripheral demyelination. Cell Mol Life Sci. 2023 Jan 9;80(1):34. PMID: 36622429

2022

Jang, Hye-Ji; Kim, Young-Yeon; Lee, Kang-Min; Shin, Jung-Eun; Yun, Jeanho; The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced Drosophila Model of Peripheral Neuropathy. Biomedicines . 2022 Apr 7;10(4):863. PMID: 35453613

Lee, Bohm; Oh, Yeonsoo; Cho, Eunhye; DiAntonio, Aaron; Cavalli, Valeria; Shin, Jung Eun; Choi, Hae Woong; Cho, Yongcheol. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury. J Biol Chem. 2022 Mar;298(3):101647. PMID: 35101451

2021

Lee JH, Oh SJ, Yun J, Shin OS. Nonstructural protein NS1 of influenza virus disrupts mito-chondrial dynamics and enhances mitophagy via ULK1 and BNIP3. Viruses. 2021 Sep 15;13(9):1845. doi: 10.3390/v13091845. PMID: 34578425. PMCID: PMC8473137

Oh SJ, Lim BK, Yun J, Shin OS. CVB3-Mediated Mitophagy Plays an Important Role in Viral Replication via Abrogation of Interferon Pathways. Front Cell Infect Microbiol. 2021 Jul 6;11:704494. doi: 10.3389/fcimb.2021.704494. eCollection 2021. PMID: 34295842. PMCID: PMC8292102

Jeon Y, Shin JE, Kwon M, Cho E, Cavalli V, Cho Y. In vivo delivery of STC2 promotes axon regeneration in sciatic nerves. Mol Neurobiol. 2021 Feb;58(2):750-760. doi: 10.1007/s12035-020-02155-2. Epub 2020 Oct 4. PMID: 33011858.

2020

Kim YY, Yoon JH, Um JH, Jeong DJ, Shin DJ, Hong YB, Kim JK, Kim DH, Kim C, Chung CG, Lee SB, Koh H, Yun J. PINK1 alleviates thermal hypersensitivity in a paclitaxel-induced Drosophila model of peripheral neuropathy. PLoS One. 2020 Sep 17;15(9):e0239126. doi: 10.1371/journal.pone.0239126. PMID: 32941465; PMCID:
PMC7498067.

Lee J, Shin JE, Lee B, Kim H, Jeon Y, Ahn SH, Chi SW, Cho Y. The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15955-15966. doi: 10.1073nas.1920829117. Epub 2020 Jun 17. PMID: 32554499; PMCID: PMC7355016.

Yi JH, Jeon J, Kwon H, Cho E, Yun J, Lee YC, Ryu JH, Park SJ, Cho JH, Kim DH. Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms.
Int J Mol Sci. 2020 May 13;21(10):3454. doi: 10.3390/ijms21103454. PMID: 32414166; PMCID: PMC7278964.

Kim YY, Um JH, Yoon JH, Lee DY, Lee YJ, Kim DH, Park JI, Yun J. p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria duringcellular senescence. FASEB J. 2020 Feb;34(2):2451-2464. doi: 10.1096/fj.201901747RR. Epub 2019 Dec 13. PMID: 31908078.

Kang KH, Han JE, Hong YB, Nam SH, Choi BO, Koh H. Human HSPB1 mutation recapitulates features of distal hereditary motor neuropathy (dHMN) in Drosophila. Biochem Biophys Res Commun. 2020 Jan 1;521(1):220-226. doi: 10.1016/j.bbrc.2019.10.110. Epub 2019 Oct 17. PMID: 31630804.

2019

Jeon J, Kwon H, Cho E, Kim KS, Yun J, Lee YC, Kim DH. The effect of coniferaldehyde on neurite outgrowth in neuroblastoma Neuro2a cells. Neurochem Int. 2019 Dec;131:104579. doi: 10.1016/j.neuint.2019.104579. Epub 2019 Oct 12. PMID: 31614166.

Kang KH, Han JE, Hong YB, Nam SH, Choi BO, Koh H. Human HSPB1 mutation recapitulates features of distal hereditary motor neuropathy (dHMN) in Drosophila. Biochem Biophys Res Commun. 2020 Jan 1;521(1):220-226. doi: 10.1016/j.bbrc.2019.10.110. Epub 2019 Oct 17. PMID: 31630804.

Kim YY, Um JH, Yoon JH, Kim H, Lee DY, Lee YJ, Jee HJ, Kim YM, Jang JS, Jang YG, Chung J, Park HT, Finkel T, Koh H, Yun J. Assessment of mitophagy in mt-Keima Drosophila revealed an essential role of the PINK1-Parkin pathway in mitophagy induction in vivo. FASEB J. 2019 Sep;33(9):9742-9751. doi:10.1096/fj.201900073R. Epub 2019 May 23. PMID: 31120803.

2018

Kim EY, Kang KH, Koh H. Cyclophilin 1 (Cyp1) mutation ameliorates oxidative stress-induced defects in a Drosophila DJ-1 null mutant. Biochem Biophys Res Commun. 2018 Nov 2;505(3):823-829. doi: 10.1016/j.bbrc.2018.10.014. Epub 2018 Oct 6. PMID: 30297105.

Kim YY, Um JH, Yun J. A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence. J Vis Exp. 2018 Aug 12;(138):57890. doi: 10.3791/57890. PMID: 30148482; PMCID: PMC6126784.

Um JH, Kim YY, Finkel T, Yun J. Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima. J Vis Exp. 2018
Aug 12;(138):58099. doi: 10.3791/58099. PMID: 30148491; PMCID: PMC6126785.

Kim YY, Yun SH, Yun J. Downregulation of Drp1, a fission regulator, is associated with human lung and colon cancers. Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):209-215. doi: 10.1093/abbs/gmx137. PMID: 29329364.

2017

Kim YY, Jee HJ, Um JH, Kim YM, Bae SS, Yun J. Cooperation between p21 and Akt is required for p53-dependent cellular senescence. Aging Cell. 2017 Oct;16(5):1094-1103. doi: 10.1111/acel.12639. Epub 2017 Jul 9. PMID: 28691365; PMCID: PMC5595696.

Yang J, Kim MJ, Yoon W, Kim EY, Kim H, Lee Y, Min B, Kang KS, Son JH, Park
HT, Chung J, Koh H. Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH). PLoS Genet. 2017 Aug 21;13(8):e1006975. doi: 10.1371/journal.pgen.1006975. PMID: 28827794; PMCID: PMC5578699.

Kim S, Koh H. Role of FOXO transcription factors in crosstalk between mitochondria and the nucleus. J Bioenerg Biomembr. 2017 Aug;49(4):335-341. doi: 10.1007/s10863-017-9705-0. PMID: 28417222.

Um JH, Yun J. Emerging role of mitophagy in human diseases and physiology. BMB Rep. 2017 Jun;50(6):299-307. doi: 10.5483/bmbrep.2017.50.6.056. PMID: 28366191; PMCID: PMC5498140.

Jo SY, Jung IH, Yi JH, Choi TJ, Lee S, Jung JW, Yun J, Lee YC, Ryu JH, Kim
DH. Ethanol extract of the seed of Zizyphus jujuba var. spinosa potentiates hippocampal synaptic transmission through mitogen-activated protein kinase, adenylyl cyclase, and protein kinase A pathways. J Ethnopharmacol. 2017 Mar 2017.02.009. Epub 2017 Feb 4. PMID: 28167293.

2016

Asiimwe N, Yeo SG, Kim MS, Jung J, Jeong NY. Nitric Oxide: Exploring the Contextual Link with Alzheimer's Disease. Oxid Med Cell Longev. 2016;2016:7205747. doi: 10.1155/2016/7205747. Epub 2016 Dec 21. PMID: 28096943; PMCID: PMC5209623.

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<h2 class="bullet">2023</h2>
 

 Sang-Heum Han;Young Hee Kim;Su-Jeong Park;Jun-Gi Cho;Yoon Kyung Shin; Young Bin Hong; Jeanho Yun; Jin-Yeong Han; Hwan Tae Park;Joo-In Park. <a href="https://pubmed.ncbi.nlm.nih.gov/36648143/">COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20.</a> J Neurochem. 2023 Jun;165(5):660-681. PMID: 36648143 
 
Shin, Yoon Kyung; Jo, Young Rae; Lee, Seoung Hoon; Park, Hwan Tae; Shin, Jung Eun; <a href="https://pubmed.ncbi.nlm.nih.gov/36689911/">Regulation of the V-ATPase subunit ATP6V0D2 and its role in demyelination after peripheral nerve injury.</a> Biochem Biophys Res Commun. 2023 Feb 26;646:1-7. PMID: 36689911 
 
Jo, Young Rae; Oh, Yuna; Kim, Young Hee; Shin, Yoon Kyung; Kim, Hye Ran; Go, Hana; Shin, Jaekyoon; Park, Hye Ji; Koh, Hyongjong; Kim, Jong Kuk; Shin, Jung Eun; Lee, Kyung Eun; Park, Hwan Tae; <a href="https://pubmed.ncbi.nlm.nih.gov/36622429/">Adaptive autophagy reprogramming in Schwann cells during peripheral demyelination.</a> Cell Mol Life Sci. 2023 Jan 9;80(1):34. PMID: 36622429

<h2 class="bullet">2022</h2>
 

 Jang, Hye-Ji; Kim, Young-Yeon; Lee, Kang-Min; Shin, Jung-Eun; Yun, Jeanho; 
<a href="https://pubmed.ncbi.nlm.nih.gov/35453613/">The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced Drosophila Model of Peripheral Neuropathy.</a> Biomedicines . 2022 Apr 7;10(4):863. PMID: 35453613 
Lee, Bohm; Oh, Yeonsoo; Cho, Eunhye; DiAntonio, Aaron; Cavalli, Valeria; Shin, Jung Eun; Choi, Hae Woong; Cho, Yongcheol. <a href="https://pubmed.ncbi.nlm.nih.gov/35101451/">FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury.</a> J Biol Chem. 2022 Mar;298(3):101647. PMID: 35101451

Lee JH, Oh SJ, Yun J, Shin OS. <a href="https://pubmed.ncbi.nlm.nih.gov/34578425/ ">Nonstructural protein NS1 of influenza virus disrupts mito-chondrial dynamics and enhances mitophagy via ULK1 and BNIP3.</a> Viruses. 2021 Sep 15;13(9):1845. doi: 10.3390/v13091845. PMID: 34578425. PMCID: PMC8473137 Oh SJ, Lim BK, Yun J, Shin OS. <a href="https://pubmed.ncbi.nlm.nih.gov/34295842/">CVB3-Mediated Mitophagy Plays an Important Role in Viral Replication via Abrogation of Interferon Pathways.</a> Front Cell Infect Microbiol. 2021 Jul 6;11:704494. doi: 10.3389/fcimb.2021.704494. eCollection 2021. PMID: 34295842. PMCID: PMC8292102 Jeon Y, Shin JE, Kwon M, Cho E, Cavalli V, Cho Y. <a href="https://pubmed.ncbi.nlm.nih.gov/33011858/">In vivo delivery of STC2 promotes axon regeneration in sciatic nerves.</a> Mol Neurobiol. 2021 Feb;58(2):750-760. doi: 10.1007/s12035-020-02155-2. Epub 2020 Oct 4. PMID: 33011858.

Kim YY, Yoon JH, Um JH, Jeong DJ, Shin DJ, Hong YB, Kim JK, Kim DH, Kim C, Chung CG, Lee SB, Koh H, Yun J. <a href="https://pubmed.ncbi.nlm.nih.gov/32941465">PINK1 alleviates thermal hypersensitivity in a paclitaxel-induced Drosophila model of peripheral neuropathy.</a> PLoS One. 2020 Sep 17;15(9):e0239126. doi: 10.1371/journal.pone.0239126. PMID: 32941465; PMCID: 
 PMC7498067. Lee J, Shin JE, Lee B, Kim H, Jeon Y, Ahn SH, Chi SW, Cho Y. <a href="https://pubmed.ncbi.nlm.nih.gov/32554499">The stem cell <a href="https://pubmed.ncbi.nlm.nih.gov/32554499">marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling.</a> Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15955-15966. doi: 10.1073nas.1920829117. Epub 2020 Jun 17. PMID: 32554499; PMCID: PMC7355016. 
 Yi JH, Jeon J, Kwon H, Cho E, Yun J, Lee YC, Ryu JH, Park SJ, Cho JH, Kim DH. <a href="https://pubmed.ncbi.nlm.nih.gov/32414166">Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms.</a> 
 Int J Mol Sci. 2020 May 13;21(10):3454. doi: 10.3390/ijms21103454. PMID: 32414166; PMCID: PMC7278964. Kim YY, Um JH, Yoon JH, Lee DY, Lee YJ, Kim DH, Park JI, Yun J. <a href="https://pubmed.ncbi.nlm.nih.gov/31908078">p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria duringcellular senescence.</a> FASEB J. 2020 Feb;34(2):2451-2464. doi: 10.1096/fj.201901747RR. Epub 2019 Dec 13. PMID: 31908078. 
 Kang KH, Han JE, Hong YB, Nam SH, Choi BO, Koh H. <a href="https://pubmed.ncbi.nlm.nih.gov/31630804">Human HSPB1 mutation recapitulates features of distal hereditary motor neuropathy (dHMN) in Drosophila.</a> Biochem Biophys Res Commun. 2020 Jan 1;521(1):220-226. doi: 10.1016/j.bbrc.2019.10.110. Epub 2019 Oct 17. PMID: 31630804.

Jeon J, Kwon H, Cho E, Kim KS, Yun J, Lee YC, Kim DH. <a href="https://pubmed.ncbi.nlm.nih.gov/31614166">The effect of coniferaldehyde on neurite outgrowth in neuroblastoma Neuro2a cells.</a> Neurochem Int. 2019 Dec;131:104579. doi: 10.1016/j.neuint.2019.104579. Epub 2019 Oct 12. PMID: 31614166. 
 Kang KH, Han JE, Hong YB, Nam SH, Choi BO, Koh H. <a href="https://pubmed.ncbi.nlm.nih.gov/31630804">Human HSPB1 mutation recapitulates features of distal hereditary motor neuropathy (dHMN) in Drosophila.</a> Biochem Biophys Res Commun. 2020 Jan 1;521(1):220-226. doi: 10.1016/j.bbrc.2019.10.110. Epub 2019 Oct 17. PMID: 31630804. 
 Kim YY, Um JH, Yoon JH, Kim H, Lee DY, Lee YJ, Jee HJ, Kim YM, Jang JS, Jang YG, Chung J, Park HT, Finkel T, Koh H, Yun J. <a href="https://pubmed.ncbi.nlm.nih.gov/31120803">Assessment of mitophagy in mt-Keima Drosophila revealed an essential role of the PINK1-Parkin pathway in mitophagy induction in vivo.</a> FASEB J. 2019 Sep;33(9):9742-9751. doi:10.1096/fj.201900073R. Epub 2019 May 23. PMID: 31120803. 
 
<h2 class="bullet">2018</h2> 
 Kim EY, Kang KH, Koh H. <a href="https://pubmed.ncbi.nlm.nih.gov/30297105">Cyclophilin 1 (Cyp1) mutation ameliorates oxidative stress-induced defects in a Drosophila DJ-1 null mutant.</a> Biochem Biophys Res Commun. 2018 Nov 2;505(3):823-829. doi: 10.1016/j.bbrc.2018.10.014. Epub 2018 Oct 6. PMID: 30297105. 
 Kim YY, Um JH, Yun J. <a href="https://pubmed.ncbi.nlm.nih.gov/30148482">A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence.</a> J Vis Exp. 2018 Aug 12;(138):57890. doi: 10.3791/57890. PMID: 30148482; PMCID: PMC6126784. 
 Um JH, Kim YY, Finkel T, Yun J. <a href="https://pubmed.ncbi.nlm.nih.gov/30148491">Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima.</a> J Vis Exp. 2018 
Aug 12;(138):58099. doi: 10.3791/58099. PMID: 30148491; PMCID: PMC6126785. 
 Kim YY, Yun SH, Yun J. <a href="https://pubmed.ncbi.nlm.nih.gov/29329364">Downregulation of Drp1, a fission regulator, is associated with human lung and colon cancers.</a> Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):209-215. doi: 10.1093/abbs/gmx137. PMID: 29329364. 
 
 
<h2 class="bullet">2017</h2> 
 Kim YY, Jee HJ, Um JH, Kim YM, Bae SS, Yun J. <a href="https://pubmed.ncbi.nlm.nih.gov/28691365">Cooperation between p21 and Akt is required for p53-dependent cellular senescence.</a> Aging Cell. 2017 Oct;16(5):1094-1103. doi: 10.1111/acel.12639. Epub 2017 Jul 9. PMID: 28691365; PMCID: PMC5595696. 
 Yang J, Kim MJ, Yoon W, Kim EY, Kim H, Lee Y, Min B, Kang KS, Son JH, Park 
 HT, Chung J, Koh H. <a href="https://pubmed.ncbi.nlm.nih.gov/28827794">Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).</a> PLoS Genet. 2017 Aug 21;13(8):e1006975. doi: 10.1371/journal.pgen.1006975. PMID: 28827794; PMCID: PMC5578699. 
 Kim S, Koh H. <a href="https://pubmed.ncbi.nlm.nih.gov/28417222">Role of FOXO transcription factors in crosstalk between mitochondria and the nucleus.</a> J Bioenerg Biomembr. 2017 Aug;49(4):335-341. doi: 10.1007/s10863-017-9705-0. PMID: 28417222. 
 Um JH, Yun J. <a href="https://pubmed.ncbi.nlm.nih.gov/28366191">Emerging role of mitophagy in human diseases and physiology.</a> BMB Rep. 2017 Jun;50(6):299-307. doi: 10.5483/bmbrep.2017.50.6.056. PMID: 28366191; PMCID: PMC5498140. 
 Jo SY, Jung IH, Yi JH, Choi TJ, Lee S, Jung JW, Yun J, Lee YC, Ryu JH, Kim 
 DH. <a href="https://pubmed.ncbi.nlm.nih.gov/28167293">Ethanol extract of the seed of Zizyphus jujuba var. spinosa potentiates hippocampal synaptic transmission through mitogen-activated protein kinase, adenylyl cyclase, and protein kinase A pathways.</a> J Ethnopharmacol. 2017 Mar 2017.02.009. Epub 2017 Feb 4. PMID: 28167293. 
 
<h2 class="bullet">2016</h2> 
 Asiimwe N, Yeo SG, Kim MS, Jung J, Jeong NY. <a href="https://pubmed.ncbi.nlm.nih.gov/28096943">Nitric Oxide: Exploring the Contextual Link with Alzheimer's Disease.</a> Oxid Med Cell Longev. 2016;2016:7205747. doi: 10.1155/2016/7205747. Epub 2016 Dec 21. PMID: 28096943; PMCID: PMC5209623.